I made it through undegrad and a doctorate without meds. Well actually I was briefly on paxil for panic attacks during that time, for maybe a year or year and a half. Both were pretty difficult even though I'm really good at school. If I had to do it again I wouldn't try to work while I was in my doctorate program (stupid and so stressful) and I would be medicated (I wasn't diagnosed yet at that time though I'm pretty sure I was already suffering from bp). I think it's possible I would just be sure you had really good self-care strategies in place and like the pp, I'm not sure why you would want to try to do that unmedicated. It's stressful enough on it's own without adding in the sensitivity to schedule changes and stress.