I have been on Topamax now since about Sept. and yes it does help you to lose weight. Not a huge substantial amount. I will be adding in Remeron very shortly and I know the side effect for that is weight gain but the only reason that I agree to try the Remeron in the first place was because I could stay on the Topamax which really does help to lose the weight gain caused by other medications.

Maybe if you went to your doctor and asked about trying Topamax along with the Remeron to combat the weight gain would be a good idea. I will warn though that Topamax is expensive however I know here in Canada there is a generic version so that is cheaper.

Good luck