For me and the antidepressants that worked, after maybe 4-6 weeks I could feel something happening, a sort of new feeling. Almost like I was a dark room and someone let a little light in. So for me it was very clear. After a few more weeks I had the full effect and life just felt different to me. Something that had seemed like an impossible chore became quite easy. Now I have never been completely nondepressed on meds, but big difference, yea. I noticed it most on my energy levels.

When I was on a different type of med, lamictal, I felt a huge difference the second day of treatment. I don't know if I would have had further bettering because I had to stop because a med allergy. But I know the med had an almost instant effect on me that was amazing. Instead of my head being filled with many and quite tedious and negative thoughts, my thought process sort of cleared up. Was like my head was a nice empty space that someone had cleaned and taken the garbage out, LOL.

When a med didn't work for me, I didn't really question my experience. I never asked anyone else if they saw a difference. Maybe I should have, but I didn't think that far.