Im starting to become curiouser about clozaril. Metabolic syndrome seems to be the biggest issue. Frequent blood tests should catch the white cell count problem that is prevalent only in a minority of cases. It seems its positive in much of the typical concerns of antipsychotic treatment. Positive on prolactin , positive for depression, possibly cuts out additional side effects on anti depressants , possibly no need to take any, positive on qt prolongation , positive for sexual libido, positive on td and es and Parkinsonism, and of course overall better efficacy. Its beginning to intrigue me.