Yes my pdoc is very well aware of it. I have very treatment resistant depression that comes and goes in cycles. For most of my life, although very deep in severity, they only lasted three weeks or so. In the last five years they are lasting months at a time. The current one is not as severe but has lasted six months now.

It is very hard to tell which drugs may have helped. I have taken so many and switched and upped doses and all of that for such a long period of time it is all a big blur. I have kept lots of mood logs over the years but they have all been lost due to hard drive crashes or I just burned them. I was in the habit of journaling alot and then just burning the notebooks to let it go. Worked for me but now I have no data to look back on. Effexor and Celexa were always my go to ones. They always seemed to work the best in combination. The thing is I have taken them so often and so long they have pooped out. Effexor has been the one I have taken the most and was the most effective but I have given up on it. Now I am on to the new ones and there are not that many. Tried Abilify with Pristiq and with Effexor for a couple of years when it first came out. I did better on Pristiq. I may try that one again. My doc likes the SNRI's as they are supposed to be activating and my biggest complaint has always been no motivation. Currently ChangingMyMind is finding Pristiq is killing her motivation so who knows. She has only been taking it a week so I hope she sticks it out and gives it a chance.