Aglomelatine is a melatonin based drug, I believe. I would like to try it because everything else has either pooped or causes unendurable side effects. Sadly, not licensed for depression in the UK and not available off-label without a pdoc (no I won't indulge that rant again you all know it so well, ok just a little whinge then).

I would also be open to ECT again (same problem no pdoc). I'd recommend it (it didn't "cure" me but it kept my depressions manageable for a good number of years). I think it would start with the full 12 sessions and then followed up by weekly (maybe slightly less frequently) top-ups. I found it far less scary than the psychotic depression I was having in my mid 20s. I also agreed to it because I figured that I would be in oblivion for half an hour three times a week and that could only be good (hardly informed consent). As to the side effects, well they were mostly short term memory loss ( kept a journal so I could fill in the blanks and in severe depressive episodes my memory isn't good anyway) and some confusion (but I was psychotic so again how much of that was the treatment and how much was the illness idk). I think I was going to try lithium at one time, but I repsonded so well to the ECT it was forgotten about. I think I might ask my GP about that one, cos if its in my notes (even from years back) he might be able to Rx without a pdoc.

I've previously been Dx as unipolar, then cyclothymic (the ups aren't high enough for bipolar but the downs are deep depressions so not dysthymia either), now severe recurrent depressive disorder, but basically, I have cyclical severe depressions, though I managed a good ten years in near total remission with only minor depressive symptoms, thanks to ECT.