Well it does work on histamine a little bit but not as much as the others thus less weight gain...the APs were initially developed as a potent antihistamine and a lot of that structure remains in the whole class so unless taking a standard anti-histamine for your allergies or cold causes you to have anxiety I doubt that's the problem. So what I'm saying is for risperidone we know 20-30 receptors it binds to but for latuda maybe 5? You can't figure out the differences if the studies of the other receptors haven't been done...your drug is too new to answer the question....