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What would cause a person to go against their own nature?
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Confusion. It's extremely easy to get confused and fumble with your identity especially if a person is suffering from a mental disorder.
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very insightful. Psychologist Donald Winnicot called it "the false self" - you hide your true feelings - as you say, go against your nature
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Alan Watts (Eastern Philosopher, Lecturer) talks about Western Society and how the "true self" is killed. The Hindu religion is based around the fact that the true self is smothered and consequently does not show itself.