most of the meds that work on seratonin in a certain way, I don't know how, cause bruxism, which is teeth clenching/ grinding which leads to tmj. I have never had tmj before until I tried lexapro, Zoloft did it to me as well. I'm on Wellbutrin though with no problems and Haldol. I have schizoaffective and the haldol about kills me, though its my miracle drug, so we were looking for a seratonin based antidepressant to help raise those levels and get my life back without spinning me into a bipolar cycling like so many of the antidepressants do. It is a balancing act. I know I did some sort of cheek swab that my pdoc took and it says i'm a rapid metabolizer of almost all the antipsychotics. Thus, I've tried them, they failed and I ended up on haldol. Best of luck to you. Watch out for bruxism with the antidepressants because that is what is flaring up your tmj. Horrible!