Hi, I am new to this site. Just wanted to give some hope to those that are trying Fetzima. Today is the 19th day I have taken it (40mg). It is also the 2nd day that I feel AWESOME!!! Not depressed (and the weather is disgusting which usually has me in bed all day, so something must be working), I have the drive and energy to clean my house and do laundry for the first time in 3 weeks, and feel overall "happy". I will say, the first 17 days of me taking this medication, I did not feel good, and, at times, I thought it was making my depression worse (which I never thought was possible). I almost said 'eff it' and stopped taking it, but I was so desperate to feel better, I continued taking it. I had many of the side-effects others have described (nausea, agitation, moody, worsening of depression, etc.) in the beginning, but decided to keep on truckin' and give it a chance. I am SO GLAD that I did! Today is really the first day I feel alive and well again, and I am so excited! I will re-post in another few weeks to let y'all know if my mood stays this way! (I have been keeping a mood journal so I won't forget )

Best of luck to all the rest of you. I know it sucks in the beginning of med changes, but sometimes if you stick it out for a few weeks and give the medication a chance, it really does work!