I gained 80 lbs in 8 weeks when I was first diagnosed and my doc put me on Depakote. It really helped with my symptoms so I took it for a few years. But then I switched to Geodon and I lost 60 of those 80 lbs but I cant seem to get rid of the last 20 lbs. I am also taking zyprexa prn for psychosis but so far I haven't gained any weight. Ive been on metformin for 15 years cause Im diabetic and I haven't seen any effect on my weight one way or the other. My bipolar daughter was taking Depakote for about a year until she got pregnant and had to go off it and it never effected her weight. I guess everyone is different.