Yes! I'm truly frightened at how severe my symptoms have become. I'm 51. Until I was 50 I was more classically bipolar 2 ("good" hypomanias that were at least somewhat fun and productive, and very creative...terrible depressions, but they were quite treatable). Over the past year my depressions have become very deep and riddled with anxiety and agitation. The hypomanias are very negative and horribly unpleasant...also anxiety/agitation, fear that borders on or is delusional, irritability - and the mixed states are a constant. Meds that were remarkably helpful before are just so-so now. I'm really struggling with my mental state, more so than ever before in my life because before meds were very stabilizing. Most days, at some point, I feel desperate.