I was not on any medication until I was well into my 40's...I have been on and off of them for the past 4 years. I think it is certainly possible to be off of them, and hope to be in the very near future again. These pills are not a cure, in my opinion. My wife was on an AD and a mood stabilizer. She's doing fine on nothing at all now. And I did very well off of all medication for well over a year.