I started Cymbalta three weeks ago. At 60mg, I've only very mild GI side effects but I have terrible earache (weird but listed as a side effect). According to the med leaflet, the effect on chronic pain takes several months to build up so don't expect miracles. I don't seem to be getting headaches (discounting the earache) and that's a bonus. Most anti-depressants seem to irritate my bladder but Cymbalta hasn't so far. All in all, I'd say give it a go.