I guess the answer must lie somewhere in between, physiologically. What works well for some may not have the same effect on others. My husband KNOWS that his Adderall isn't working as well as it used to but is afraid to say anything for fear the alternative is worse (take something that helps a touch versus something that may prove to help even less). I think the answer is to keep trying until you find the right combination. I hope.... The alternative is unthinkable to me!