Quote:
Originally Posted by Miguel'smom
So explaining science with pdoc: anti-psychotics block dopemine. So he feels to much dopimen causes psychosis. SNRI increase dopemine and norepinephrine. I'm currently on 75 mg sr 1x day of welbutrin which is a SNRI.
He doesn't want me off the welbutrin because it saved my life but he doesn't care for a side effect of psychosis but can't be sure its a side effect or responds to stress.
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So why not just back down a little in the Wellbutrin...I didn't realize that was the AD you were on it's for sure known to induce psychosis....if you add an AP it won't even matter whether you are taking Wellbutrin or not the effects will be blocked at the dopamine receptor by the AP so the signal won't get through. There is typically 80-90% receptor occupancy for the D2 antagonists so people taking them don't get anywhere near the normal level of dopamine signaling even when the receptor numbers increase to compensate for the blockade. Often we will develop blunted affect ie not smile etc as a result of the drug. If you are really worried about losing the beneficial effects of Wellbutrin an AP is not going to help you....it's roughly like Wellbutrin turns on the faucet so the water is flowing but an AP is the stopper in the sink so none of that will make it downstream.
The only one you might try is abilify because it's a partial agonist at dopamine but it's still going to block any Wellbutrin effect unless it's acting by D1 or some other non D2 receptor.