SNRI's work on serotonin and norepinephrine. At high doses there is some secondary action on dopamine, but that is not the main action. Wellbutrin is an NDRI, which works in norepinephrine and dopamine.

There is a benefit to taking wellbutrin with an AP, even though AP's primarily block dopamine. There are multiple pathways for the neurotransmitters, so it is not as simple as blocking or increasing, meds can do a little of both. Wellbutrin can help with blunted affect caused by APs, although it hasn't worked that well for that in me. Wellbutrin's antidepressant effects may be reduced by an AP, but they are not totally canceled out.

If you have psychosis an AP is important because the longer the psychosis goes, the more difficult it is to treat.

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