I barely tried Seroquel for maybe 2 days quite some time ago...but I've tried many other APs. They never worked for me and only made me very ill (think 24/7 flu) and I was disoriented to the point of falling, losing my balance, and my vision going blurry for a few minutes (with perfect vision!). I'm 26 and seriously thought I would need a walking stick if I must be on these meds! It was so intense and I couldn't stand it. All of them did that to me. I have tried Latuda and Abilify and I believe one other. So it is not even that medication is not helping, the problem is my body rejects a lot of them.