It depends on what you need medication for. Sometimes SSRIs (anti-depressants) are actually prescribed as a treatment for Crohn's. My best friend takes Lexapro specifically for Crohn's -- not as a treatment for anxiety or depression. Some SSRIs (Celexa and Lexapro) and Clonazepam actually helped with my GI problems and resulted in fewer IBS flare-ups and less nausea.

This is something you need to talk to your doctor about though -- be open and clear about what's bothering you, what you want the medication to help you with, and your physical problems. The more information you give your doctor, the better able to help you he/she will be.

As for meds that don't make you tired during the day, once again it depends on what you need to be treated for. I can only speak from my own experience. I take Lexapro every day and it doesn't make me tired. I recently had to switch from taking it at night to taking it in the morning instead because it was keeping me awake at night. Now that I'm taking it in the day, I have more energy and I sleep well at night. We're all unique, though, so medications can affect us differently.

A lot of medications have been hard on my digestive system for the first week or two, but once my body is adjusted to the medication, my GI problems almost always get better rather than worse.

So, talk to your doc. Only he/she can tell you what's best for you. Make sure you let your doc know about all your concerns -- psychological, emotional and physical. It can be very dangerous to try to diagnose yourself and choose drugs yourself. Good luck. I hope your doctor can help you to feel better.