I've taken a ton of APs. The combo of seroquel and haldol worked pretty good for awhile but then my symptoms changed and I became more paranoid. Then I started having too many side effects from them because I had to take them at high doses. I also have severe anxiety. My current med combo seems okay--latuda, seroquel and a couple mood stabilizers. The latuda can cause some anxiety--especially the first few months you take it--but, I've adjusted to it. The latuda helps my thinking and paranoia more than any other AP I've taken. And, the seroquel I take also helps with the anxiety.