Ro yes I was on one antidepressant for about 9 month's and it stopped working while still taking the pills. Then MD tried to up dose and made whole body hurt that I could not move. Then MD switched to different SNRI and I have chronic pain in areas jaw, head, neck....I had to stop that antidepressant after 3 day's cause my jaw was locking and more pain everywhere. Now on no antidepressants till I get diagnostic testing etc for MS. So I am trying to manage but the depression is winning! Im just taking it day by day and withdraw from school.