Quote:
Originally Posted by ZehR
@ SometimesPsychotic (And everyone else), I'm learning basic genetics for my last topic in grade 12 biology and I have to do a presentation on genetics in relation to disorders so I picked schizophrenia because it seems pretty obvious that there's a genealogical component in relation to environmental factors. Something like 55/45%. My previous presentation was on prenatal methamphetamine exposure which can lead to schizophrenia and other disorders so I thought ya..
You seem to know a lot about this stuff so I'm just asking like what specific genes (because there's thousands so just in general) are they? I've found genes like DISC1, DISC2, COMT, etc. Just a few paragraphs on what you know such as statistics on generations etc would be really helpful. I disabled private messaging but no one cares if I post here I'm sure.
The more I look at it, It seems like people are just getting it through psychological stress and environmental factors such as abuse etc. It is genetics that are involved but idk I might have to change the disorder but I've gone too far into it now and I'm good at researching..
Btw the info on deterioration in grey matter seems helpful as well because that's what these genes lead to when activated I think.
Thanks
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So honestly I'd pick another topic unless you want to do something incredibly vague with hundreds of potential genes. We went through a lot of this when a couple of us got our genome sequenced---there are some snps about 185-186 that are common so they are on chips where you can get your sequence at that snp but there also seem to be a lot of de novo mutations---rare variants----so here is a link to us talking about the outcome of our genomes some of the genes and their phenotypes are in there starting around page 31 and beyond
https://forums.psychcentral.com/schi...l-news-31.html
Basically you can have any one of these mutations and be fine or develop sz its just your tendency increases with more of these mutations....some are quite common though where like 50% of the population will have a mutation. The large GWAS studies I talk about the latest results here....
http://forums.psychcentral.com/schiz...-genetics.html
So its not any single mutation----its actually been described as a pathway disorder so a mutation of any of the proteins in a signaling pathway will have the same outcome as far as phenotype.
Even with clear sz risk factors like disc----there is the issue that it appears to increase risk for a psychiatric condition which could be bipolar or depression and not just sz----if they take those proteins and knock them out in a mouse it actually generates an autism phenotype instead.
So the long and short of it is there is no mutation which guarantees a sz phenotype----everybody has a different mutation and you also need a stressor or developmental progression to trigger the disease. For the developmental aspect its been proposed that neural pruning is somehow misregulated leading to issues in neuron connectivity.