OP - YES...I had an awful breakdown this past winter and was put on a high dose of Zoloft. I thought I was going completely, entirely insane. The agitation/anxiety sensation was UNBEARABLE. I felt completely crazy and could not help but tear at my cuticles, move my leg constantly until it was very sore (and still couldn't stop), I was an emotional mess. My p-doc described the experience I had as a "negative hypomania". Dropped the Zoloft dose down to 100mg (had been at 200mg). I'm at 100mg, but plan to drop it down to 75 or even 50. I really feel for you - what you've described is pure hell. Please contact your p-doc ASAP...imo, your Zoloft dose needs to go down. Best of luck to you~