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Old May 20, 2014, 06:12 PM
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nbritton nbritton is offline
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Member Since: Oct 2013
Location: Texas
Posts: 340
Quote:
Originally Posted by Sometimes psychotic View Post
No there really aren't even a lot of meta-analysis studies for negative symptoms in general---
I was searching through pubmed and actually found one meta review...

Rev Psiquiatr Salud Ment. 2011 Jul;4(3):126-43. doi: 10.1016/j.rpsm.2011.02.005. Epub 2011 Jun 14.
Efficacy of second-generation-antipsychotics in the treatment of negative symptoms of schizophrenia: A meta-analysis of randomized clinical trials.
Darbā J1, Minoves A, Rojo E, Jimenez F, Rejas J.

Abstract:

OBJECTIVES:
To determine whether second-generation-antipsychotics (SGAs) are effective for negative symptoms treatment in schizophrenia.

METHODS:
Two meta-analyses were carried out using placebo or haloperidol as comparators. The search included the following databases: Pubmed, The Cochrane Central Register of Controlled Trials, Proquest Health and Medical Complete, Science Citation Index Expanded, and Current Contents Connect. The outcome measure used was the change in negative symptoms, choosing a standardized statistic (Cohen's d) to synthesize the data.

RESULTS:
In the placebo-controlled meta-analysis, the effect sizes (Cohen's d) obtained for amisulpride, haloperidol, olanzapine, quetiapine, risperidone and ziprasidone were 0.52, 0.34, 0.43, 0.36, 0.40 and 0.46, respectively, favoring active treatment against placebo (P<0.001 in all cases). The haloperidol-controlled meta-analysis only showed a statistically significant trend favoring antipsychotics over haloperidol (Cohen's d=0.15).

CONCLUSIONS:
Most antipsychotics (amisulpride, haloperidol, olanzapine, quetiapine, risperidone and ziprasidone) are effective in the treatment of negative symptoms. Amisulpride and ziprasidone showed higher effect sizes.


Update: I think it is important to point out that this study was funded by Pfizer, the makers of ziprasidone (geodon). It's disheartening to know that the only reason amisulpride isn't approved for use in the US is simply due to it's expired patent status.

Last edited by nbritton; May 20, 2014 at 06:54 PM.
Thanks for this!
Sometimes psychotic