I can definitely empathize with this feeling, though maybe we're simply more receptive to support and praise when we're feeling good about ourselves.

I know that the times that I feel the most gratitude are when I have friends and family rallying around me as I make productive and positive strides to change my life for the better in spite of my illness...

and sometimes, when things are going especially badly, even when my mother or my best friend, or whoever, is standing in front of me saying "I'm here for you, I'll help you any way I can", it only makes me feel more isolated and angry, mocked, and patronized.

It's strange.