50 mg of Seroquel isn't a lot, so if you had to take it as a prn more than once in the day I think you will be fine. BUT - I can't say for sure, because I don't know about your medical history or what other medications you could be taking that might interact. The maximum listed daily dose of seroquel is 800mg. But most people are on a lot less than that. My thought is take an extra 50 mg prn if you feel like you need it, and get in touch with your pdoc ASAP and tell them what's up. But that is just my opinion, and I could be wrong. Also, don't mix it with grapefruit juice, because that can increase the seroquel level in your blood quite a bit.