I had gained 40 lbs on Depakote. I was on Seroquel for several years and could not lose the weight. I had changed my eating habits drastically. I recently came off the Seroquel and have already lost 18 lbs in two months. I had to come off of the Seroquel because the medicine caused me to be pre-diabetic which I am now on medicine for, and my triglycerides went thru the roof. Coming off of the Seroquel was the worst withdrawals I have ever had. I went thru hell for over a month, several days I was lying on the couch shaking and then I would sweat and then be cold. This stuff is potent in my opinion. I will never go on this medicine again.