I've nearly always been on divided doses of my meds (not sure why, but I guess when I was on heaps meant I wasn't taking so much at once)... Never noticed any diff on my AD, which has just been changed to 1x a day, but certainly with my maintainence antianxiety ones it helped. Actually, never noticed any diff when I was on a mood stabiliser either- I used to choose whether I took all at once or divided the dose (depending on how my stomach would cope with each dose) and there was never a diff... I know that with just about every med around (incl "non-drowsy/non-sedating" ones e.g. antihistamines) I have severe drowsy/sedating side-affects so the split doses prob helped eliminate as much of that as poss too...Don't know if any of this helps or not?!