I've heard that Paxil is also a weight gainer. My doctor is tapering me OFF of Seroquel at the moment specifically because of the weight gain. In the last 3 or 4 months I've gained about 25-30 pounds.

I've heard that Seroquel (and other AP's) affect not only your appatite, but your metabolism as well, which is why weight gain is almost a guarantee. You'd have to keep an extremely strict workout/eating regime in order to keep the weight off. I'm sure it's possible, but I personally simply didn't have the time needed to devote to it. I'm kind of scared to go off of it myself. I've already noticed a difference in the last few days where I seem to be talking to myself a lot more (something I haven't done since I started Seroquel) and I've just been getting more and more of a feeling of un-ease that was also really common pre-Seroquel.