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Originally Posted by Sometimes psychotic
So I had not heard of this----I wonder if it was based on your genetic analysis? You really do have the best of care
Anyway I looked it up and its a COMT inhibitor. So in some parts of the brain COMT controls the breakdown of dopamine but its tricky because both too much and too little dopamine are bad---there are two variants of COMT met/met and val/val or the heteozygote val/met. The val/met is considered normal but either met/met or val/val increases your risk of schizophrenia. I have val/val there and what that normally means is you do well in stressful situations like exams etc because you rapidly clear dopamine under stress you probably do better under stress than in your day to day---I have zero idea how that leads to increased sz but it does and even treatment resistant forms. The alternative is met/met under day to day conditions you perform amazing but give a standardized test and you will freak out and likely do worse than usual because your brain is flooded with dopamine...it's more clear to me how this leads to sz due to the dopamine hypothesis.
I'm thinking you must have the val/val variant that clears too quickly and they are wanting to slow it down a bit so you look more like the heterozygote. Thing is it probably also helps with some of the side effects for the meds that are due to dopamine inhibition---things like shaking but also cognition etc.
Anyway I think that's super cool...thanks for telling me about it....if I find out more I'll let you know.
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yes PDOC said i have val/val. the genetic test said that. Thanks so much for ur response!!!!