I take 450 wellbutrin in the AM. It is a extended release called wellbutrin XL. I know it comes in 150 mg tabs. You may want to ask your pdoc about it. Although it does cost more. For awhile I was taking 450 mg of the regular wellbutrin in 2 doses. I have always taken it in the AM or split the dose AM and early afternoon. I have never taken it at night because it is known to keep you awake. Maybe your pdoc meant AM and afternoon?