I never had the edema issue when I was on lamictal, but ended up coming off of it anyway because it wasn't working for me. I haven't been able to take ADs, either, for the same reason - drug induced mania - but with my recent plunge into suicidal depression, I had Brintellix added at the lowest dose with the hope that my mood stabilizer would keep the mani symptoms in check. So far, it doesn't seem to be working, though :T

Up until this recent episode, the latuda I'm on did work really well to treat the bipolar depression.