I have been blessed in that I was first put on Zoloft, became highly suicidal at half the dose, hospitalized for that and then put on Cymbalta in the hospital. I have been on Cymbalta for almost 7yrs now, although varying doses, and am quite happy with it. I don't remember when we added Abilify, however it too is working well. I have been on several anti-anxiety meds due to my building a tolerance to them. At one point, I was on BuSpar 3 times a day and Klonopin twice a day. I am now down to just the Klonopin and once a day. So in answer to your question, it took 3 days to find the right anti-depressant. I hope more people answer your thread so you can see how it differs from person to person.