If you have a reaction like you've described to an AD it is a strong indication of bipolar disorder.

I was prescribed 200mg Zoloft a few months ago...went into the worst "negative" hypomania I have ever experienced. Horrid agitation, anxiety, angst, extreme mixed states. it was sheer HELL. P-doc told me AD's often cause problems with bipolars. He decreased the Zoloft to 100mg. I was better, but still not at all okay. Long and miserable story short, I'm now at 50mg and doing so, so much better. The AD had triggered that hypomania. I'm actually aiming for 25mgs. at this point.