HI , your story is very similar to mine and my husbands , i havnt worked for 4 years now due to health reasons , i have no interest in anything at all , i never want to go out , and i even avoid family occasions if i can . I can honestly say i hate being this way but depression and anxiety and my own lack of self belief / confidence is what makes me this way , please dont give up on your wife , she does sound like she is suffering from some sort of depression . I hope you can get the help you both need , best wishes