ive been on a sh_t ton of meds. most all anti-depressants and anti-psychotics. right now i take vybriid (Anti depressant), invega sustenna shot, comtan, prazosin (for flashbacks and nightmares), trazedone (for sleep) and 300mg seroquel (to help the invega shot). i think the vybriid has been very good for my depression. im only on 10mg and i dont get depressed as much as i used to .