in response to Zoloft I take 50mg once a day, I have a weight problem and my doc said it would suppress my appetite, I have to lose weight because I also have high blood pressure . The zoloft does not make me tiried either it works great for me. Congrats on your running 3 miles a day that and walking is the best, I have taken walking as a excercise as well and I lost some weight so it's important these drugs don't cause weight gain.