I am not sure if I can really answer this or not...my paranoia was very mild and only lasted a short time when I was severly depressed. However, my doc gave me abilify. Its been a good drug for me--helped bring me out of a psychosis and it decreased intrusive thoughts. The paranoia went away, but I am not sure if it was the abilify or the other drugs. I am pretty sure it was the abilify. The good thing about abilify is that I have had zero side effects.