I have tried it, and did find it enjoyable...but yeah aside from causing a sense of wellbeing it does cause things too look/sound/feel different. It didn't cause me to see things that where not there at all but colors are brighter and more of them and some things like designs move....though its also possible to have bad trips especially in the wrong setting, so yeah I don't really see it as something that could be used on a daily basis for depression or anything else but provided one takes it and has a good experience it could be useful on occaissions. I've never had a bad trip on lsd but I did on mushrooms...and yes certainly not pleasant, best not to watch things that might be disturbing while tripping.