I was browsing for something entirely different and stumbled across your post - I joined this site just to reply to you as I can relate to your situation - having been there myself - well into my 30's. I can relate to the extreme emotional pain and distress it causes. Also, it's something you feel you cannot share with others around you - adding to the feeling of isolation which was already pretty strong to begin with.

My situation was slightly different (and perhaps a bit more complex) in the sense that eventually I did get into a relationship, but the complexity being that my partner suffered from similar issues as well(low self esteem primarily) - resulting in an asexual relationship for a number of years - which added to the seeming hopelessness of the situation. What worked in the end though was psychotherapy - I had an anti-therapy stance for most of my life - but I got so desperate that I felt that it couldn't really get any worse. So, long story short - after having individual therapy for a couple of years with a psychoanalyst and couples therapy for a cpl of months with a psychosexual therapist - we were finally able to consummate the relationship and get a sexual dimension to our lives.
Coming back to your immediate questions - I have no clue about the drugs that you asked about - but I do suggest getting in touch with a mental health professional and consider getting into therapy, if possible. At the very least it will help you in being able to share the feelings of pain and isolation and hopefully - get to a more long term resolution of the underlying issues.