I understand how you feel. I have been on all of the above except Zoloft. It seems nothing works well for me either. When I took Effexor, it made me so sleepy, I had to stop it. It might have worked but I couldn't stay awake to work or function so I stopped it. I don't even want to go to work this morning but I will make myself. Hang in there. There has to be hope that something will work for us. I am beginning to wonder if the answer lies in medication or something else.