I understand your logic and I can get caught up for sure in over analyzing and dwelling on causes. It is important though to identify triggers if there are any. That way you are more equipped to do some planning and CBT around that trigger and possibly avoid it triggering a depression or at least process it and hopefully make things better.

I have no doubt with me it is deeply ingrained biologically and genetically and i have a life time of experience and evidence to back that up. But situational issues do affect it and trigger it. Those issues I have to focus on processing in a healthy way. That is a part of the solution for me and not really jumping down the rabbit hole.

As far as throwing darts I was speaking specifically to me and my depression. They have no way of knowing whether Prozac or Zoloft will work better for me. There are some genetic tests now on what active metabolites we produce on about 15 antidepressants but those go more to side effects than effectiveness. I have had pdocs tell me to just pick one. That my guess was as good as theirs. The only hint they may have is what class has worked better in the past. Everyone is so different is what active metabolites we produce thus the wide range of experience people have with side effects and effectiveness. I don't see how with depression at least it is not throwing darts unless they did extensive genetic testing and blood work which they do not.