i know longer am under care of p/doc since getting off lithium completely after 35 yrs. and using internist to monitor my seroquel/klonopin. use 1/2 25mg. seroquel nightly for the best sleep with vivid dreams but 40 min. hangover in a.m. which is fine with me, but we are planning some really long distance travel from az. to fla. for 3 days; london for 3 days, then on to south africa for 2 weeks; returning from south africa thru england, staying in fla. for 3 days and then returning to az. in the past even a 1 or 2 hr. time change kicks me into mania (i'm bp2, have hypomania but no depression) and we will be flying business class (apparently lying down on seats that are similar to a bed to insure i get the best sleep possible during these trips) BUT I AM ASKING YOU TRAVELERS WHAT'S THE BEST MED. I CAN USE TO INSURE GOOD SLEEP KNOWING REGARDLESS, I WILL SUFFER DESTABILIZATION. SHOULD I INCREASE MY SEROQUEL TO 25MG. OR ADD AMBIEN TO THE MIX (I USE THIS COMBO WHEN REALLY MANIC AND UNABLE TO SLEEP WITH JUST 1/2 25MG. SEROQUEL). HAVE READ PROS AND CONS ABOUT MELOTONIN AND TRYTOPHAN. WOULD APPRECIATE ANY/ALL INPUT.