I have watched it before. I have a lot of respect for him and for Stanford research. I don't know that you can say one professors view on the matter is scientific proof. I agree with him that at least in my case it has a very biological basis. I agree it is a very debilitating and horrible disease. I have experienced it many times. I don't know that I can say it is the worse disease on earth because I cannot really compare my suffering to others. I do not walk in their shoes.

He speaks of pleasure in a very hedonistic, animal instinct sort of way. I think there are more to humans than that. For example your love of producing music and sharing it is much more than a hedonistic pursuit of pleasure. It is on a higher plane than eating or sex. A more evolved form of pleasure. It takes intelligence and creativity to do that. You get contentment and satisfaction from it. Pride that others would like it. Those are all attributes other than pure pleasure.

Let us assume that what you say if totally true. Depression is the absolute lowest and pleasure is the absolute highest. A life of depression is useless and of no value.

The question still remains, given that, what are we going to do about it??? You are avoiding that question.