Oh man I was reading the chart backwards---I'm so used to having a higher value mean more blocking but this is Ki and the higher it is the weaker the blocking effect----the only thing where olanzapine is stronger at binding than risperidone is the muscarinic receptors which are pretty much side effects based. I'm leaving the above comment because the stuff about 5ht7 is true in general and interesting but olanzapine is actually a weaker binder than risperidone. So yeah from this I have no idea---most people do respond to risperidone but they just can't tolerate the side effects.