Thank you for this! I'm the same too - normally it's long periods of one or the other but lately its been all over the place. Perhaps it's something to do with coming off one med and starting another, who knows. I seem to go from one extreme to the other, then there's just this totally flat feeling. There doesn't seem to be any "normal". It's only been a week but I think I can already feel the Effexor working. I've been getting up super early, wide awake and raring to go (which was annoying at first, but now I've been making the most of it) when normally I have to literally force myself out of bed and usually end up late for work. Normally, no medication does anything. This is the first time I've been on an SNRI though, it's always been an SSRI before, maybe that has something to do with it, again - who knows!