I am on Seroquel 25 mg at night for Bipolar Depression. I had have taking for more than 4 years. You are right about the sides effects regarding gain weight, how you feel when you wake up, but for me really works.

After a while, I did what my pdoc suggested take before I will go to bed and don't wait, go to sleep, if I am up for any reason after taking I get really hungry, but it is manageable.

About feeling so tired when I am waking up, well I change the thoughts of being in bed for another 2 hours and jump to the bathroom and clean up. Also helps that I made plans for the next day, so I have a "To Do List", etc. Anything can work.

I am not judging you, the reason I am telling you how I cope with Seroquel is because helps me so much with my anxiety, depression and it is the only med for me, just for me because everyone is different, that stop my racing thoughts.

My humble opinion, check with your pdoc till you find the right medication for you.
My best wishes, get well, stay well.
Alexia