I would assume my body made enough SAMe and/or did not like the amount/kind/additional incredients. WebMD's article listed side effects:
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It can sometimes cause gas, vomiting, diarrhea, constipation, dry mouth, headache, mild insomnia, anorexia, sweating, dizziness, and nervousness, especially at higher doses. It can make some people with depression feel anxious.
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I'd try what blwi3310 suggests and back off on the amount or change brands or just eat more eggs and fish which are high in methionine (the "M" in SAM), more protein in general and see if that helped. It is not magic, if you don't need it you could be hurting your health. Food can get you all the "parts" you need whereas taking bits and pieces of things can throw off balance of the other stuff.