Thanks metamorphosis12,

It's actually only one brand that does it so I did stop taking that brand. It was the 365 brand that did it. I now tale Jarrow without that problem. Although I think it constipates me it's the only option I have right now.

I am not taking and other drug that would interact with SAM-e. Especially Any other antidepressants. I've been taking a very low dose as well 400mg and pdoc is aware. I do appreciate the post and concern.