Ricwag and others - I'm sorry to hear you are facing these symptoms but it's so good to hear other people are experiencing this too, not just me. I have often described my irritability as a physical thing. It feels like there are glass shards in my veins. I can physically feel the irritability. At times it would make me feel very physically agitated too, like I had to do something with my arms (grab, flail) when it peaked. My meds help.